CEDENNA:

Promotes science among our youngsters.

Members

  • imprimir

Main Researchers

Cristián Vilos

Phone(s): (56 2) 2770 3902
Associate Professor, Center for Integrative Medicine and Innovative Science (CIMIS), Facultad de Medicina, Universidad Andrés Bello.
Echaurren 183, Santiago, Chile. Postal Code: 8370071

Professional Degree

  • PhD in Biotchnology, Universidad de Santiago de Chile.
  • Medical Technologist in Clinical Laboratory, Immunohematology and Blood bank.

Research Areas

  • Development of combined drug therapy based polymeric nanoparticles for colorectal cancer.
  • Advanced nanotherapies for chronic pain, as well as, the study of fundamentals of nano-bio interactions in the physiological environment.
  • Drug delivery systems based on biodegradable and biocompatible polymers.

Projects

  • Proyecto Tesis en la Industria TPI06, Programa Capital Humano Avanzado, CONICYT

Conferences

  • Formulation and characterization of magnetite-loaded PHBV nanoparticles for biomedical applications. Vilos C, Gutierrez M, Escobar R, Velásuqez LA, Denardin JC, Altbir D. Tercer worshop Chile-Mexico sobre Magnetismo, Nanociencia, y sus Aplicaciones. Los Andes, Chile, Abril 2011.
  • Uso de zeolita magnética como transportador de proteínas. Gutierrez M, Vilos C, Díaz P, Altbir D, Denardin JC, Velásquez LA, Escudey M.Tercer worshop Chile-Mexico sobre Magnetismo, Nanociencia, y sus Aplicaciones. Los Andes, Chile, Abril 2011.
  • Arenas, MC., Vilos, C., Velásquez, L., Constandil, L., Hernández, A., Laurido, C. Micropartículas de liberación sostenida de antibióticos: Estudio toxicológico en la rata. LIII Reunión Anual Sociedad de Biología de Chile. IV Reunión Anual, Santa Cruz, Chile, Noviembre 2010.
  • Cytotoxicological characterization of iron oxide nanoparticles coated with PHVB and functionalizated with antibiotics. P. Solar, C. Vilos, M. Mellado, M. Gutierrez, Y. Gonzalez, H. Cardenas, L.Velasquez. Chilean Society for cell biology XXIV annual meeting. Pucón, Chile, Noviembre, 2010.
  • Cristián Vilos, Marlen Gutiérrez, Roberto Escobar, Hugo Cárdenas, Dora Altbir, Pedro Orihuela, Luis Velásquez. Diseño y síntesis de nanoapartículas de Poly (3-hydroxybutyric acid-co-hydroxyvaleric acid) (PHBV) que contienen magnetita y antibiótico con propiedades superparamagnéticas. 8ª Conferencia Internacional de aplicaciones cientificas y clinicas de carriers magnéticos. Warnemünde / Rostock, Germany, Mayo, 2010.
  • Marlen Gutiérrez, Cristian Vilos, Roberto Escobar, Dora Altbir, Juliano C. Denardin, Luis Velásquez, Mauricio Escudey. Zeolita magnética como carrier de proteínas. 8ª Conferencia Internacional de aplicaciones cientificas y clinicas de carriers magnéticos Warnemünde / Rostock, Germany, Mayo, 2010.
  • Vilos C, Gutiérrez M, Orihuela P, Cardenas H, Velásquez L. Sistema de liberación sostenida de fármacos basado en micro y nanopartículas de PLGA. XXIII Reunión Anual Sociedad de Biología Celular de Chile, Pucón, Chile. Noviembre, 2009.
  • M. Gutiérrez, C. Vilos, D. Altbir, J.C. Denardi, M. Escudey. Remoción de Arsénico con zeolita magnética. Solidos´09, Valparaíso, Chile, Noviembre, 2009.
  • M. Gutiérrez, P. Díaz, C. Vilos, E. Espinosa, R. Calderón, L. Velásquez, P. Orihuela, D. Altbir, M. Escudey. Sistema carrier a base de zeolita magnética. XXVIII Jornadas Chilenas de Química. Chillan, Chile. Noviembre, 2009.

Invitation to Conferences

  • 2010. Micro y Nanotecnología: Nuevas estrategias terapéuticas aplicadas en humanos y animales. Seminario de difusión del Proyecto TPI06 Tesis en la Industria, del Programa de Atracción e Inserción de Capital Humano Avanzado, CONICYT. Universidad de Santiago de Chile.
  • 2010. Liberación de fármacos a partir de Micro y Nanopartículas. Feria Científica 2010, Facultad Química y Biología. Universidad de Santiago de Chile.
  • 2009. Nanotecnología una plataforma terapéutica. Reunión Sociedad Anatomía de Chile. Universidad de Talca.

Research Stays

  • Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology. Laboratory of Nanomedicine and Biomaterials, Department of Anesthesia, Brigham and Women’s Hospital-Harvard Medical School, Boston, Massachusetts, USA. Junio-noviembre 2009
  • Visiting Professor
    Laboratory of Nanomedicine and Biomaterials
    Brigham and Women’s Hospital – Harvard Medical School,
    Boston, Massachusetts, USA.
    Enero 2013- Enero 2015
  • Research Affiliate in Langer Lab
    MIT – Massachusetts Institute of Technology
    Cambridge, Massachusetts, USA.
    Enero 2013- Enero 2015

Attendance at other scientific events

  • South-America Workshop on Bioencapsulation. Valdivia, Chile, April 2011.
  • III Escuela de NanoEstructuras, Universidad Técnica Federico Santa María, 12 – 15 enero, 2010, Valparaíso- Chile.
  • Chilean Science Meets the Max Planck Institutes Max Plank-CONICYT- Centro Interdisciplinario de Neurociencias de la Universidad de Valparaíso (CINV), Valparaíso, Enero 11-13, 2010, Chile.
  • 7th International Conference on the Scientific and Clinical Applications of Magnetic Carriers. May 2008. Vancouver, Canada.
  • XIV Chilean Congress of Clinical Chemistry. December 2005. Reñaca. Chile.

Publications

2018
  1. J. Ábrigo, A.A. Elorza, C.A. Riedel, C. Vilos, F. Simon, D. Cabrera, L. Estrada, C. Cabello-Verrugio
    Role of Oxidative Stress as Key Regulator of Muscle Wasting during Cachexia
    Oxidative Medicine and Cellular Longevity Volume 2018, Article ID 2063179, 17 pages
  2. M.F. Matus, M. Ludueña, C. Vilos, I. Palomo, M.M. Mariscal
    Atomic-level characterization and cilostazol affinity of poly(lactic acid) nanoparticles conjugated with differentially charged hydrophilic molecules
    Beilstein J. Nanotechnol. 2018, 9, 1328–1338
  3. J. Ábrigo, F. Campos, F. Simon, C. Riedel, D. Cabrera, C. Vilos, C. Cabello-Verrugio
    TGF-β requires the activation of canonical and non-canonical signalling pathways to induce skeletal muscle atrophy
    Biol. Chem. 2018; 399(3): 253-264
  4. M.F. Matus, C. Vilos, B.A. Cisterna, E. Fuentesa, I. Palomo
    Nanotechnology and primary hemostasis: Differential effects of nanoparticles on platelet responses
    Vascular Pharmacology 101 (2018) 1-8

2017
  1. Won Il Choi, A. Sahu, C. Vilos, N. Kamaly, Seong-Min Jo, Jin Hyung Lee, Giyoong Tae
    Bioinspired Heparin Nanosponge Prepared by Photo-crosslinking for Controlled Release of Growth Factors
    Scientific Reports 7, Article number: 14351

2016
  1. B.A Cisterna, N. Kamaly, Won Il Choi, A. Tavakkoli, O.C. Farokhzad, C. Vilos
    Targeted nanoparticles for colorectal cancer
    Nanomedicine (2016) 11, 2443-2456 | Published Sep

2017
  1. Francisca Uribe, M. Cantín, J.P. Alister, C. Vilos, R. Fariña, S. Olate
    Proteína Morfogenética Ósea y su Opción como Tratamiento de la Fisura Alveolar
    Int. J. Morphol., 35(1):310-318, 2017 | Published Mar
  2. E. Fuentes, B. Yameen, Soung- Jae Bong, C. Salvador-Morales, I. Palomo, I. Palomo, C. Vilos
    Antiplatelet effect of differentially charged PEGylated lipid-polymer nanoparticles
    Nanomedicine: Nanotechnology, Biology, and Medicine 13 (2017) 1089-1094 | Published April
  3. J.P. Peñaloza, V. Márquez-Miranda, M. Cabaña-Brunod, R. Reyes-Ramírez, F.M. Llancalahuen, C.Vilos, F. Maldonado-Biermann, L.A. Velásquez, J.A. Fuentes, F.D. González-Nilo, M. Rodríguez-Díaz, Carolina Otero
    Intracellular trafficking and cellular uptake mechanism of PHBV nanoparticles for targeted delivery in epithelial cell lines
    Peñaloza et al. J Nanobiotechnol (2017) 15:1 | Published 3 Jan
  4. Won Il Choi, B. Yameen, C. Vilos, A. Sahu, Seong-Min Jo, Daekyung Sung, Giyoong Tae
    Optimization of fibrin gelation for enhanced cell seeding and proliferation in regenerative medicine applications
    Polym. Adv. Technol. 2017, 28 124-129 | Published Jan
  5. M.P. Pinto, M. Arce, B. Yameen, C. Vilos
    Targeted brain delivery nanoparticles for malignant gliomas
    Nanomedicine 12 (2017) 59-72; Published (web) 23 Nov

2016
  1. W.I. Choi, A. Sahu, C. Vilos, J.H. Lee, S. Kim, Y.K. Hong, D. Sul, S.W. Hwang, S.H. Leeg, G. Tae
    Chitosan functionalized thermosponge nano-carriers for prolonged retention and local delivery of chymopapain at the nucleus pulposus in porcine discs ex vivo
    RSC Adv., 2016,6, 90967-90972; Published (Web) 14 Sep 2016
  2. B.A. Cisterna, N. Kamaly, Won Il Choi, A. Tavakkoli, O.C. Farokhzad, C. Vilos
    Targeted nanoparticles for colorectal cancer
    Nanomedicine (2016) 11, 2443-2456; Published Sep 2016
  3. O. Valdés Lizama, C. Vilos, E. Durán-Lara
    Techniques of Structural Characterization of Dendrimers
    Current Organic Chemistry, 2016, 20, 2591-2605; Published Sep 2016
  4. C. Salvador-Morales, B. Brahmbhatt, V. Márquez-Miranda, I. Araya-Duran, J. Canan, F. Gonzalez-Nilo, C. Vilos, J. Cebral, F. Mut, R. Lohner, B. Leong, G. Sundaresan, J. Zweit
    Mechanistic Studies on the Self-Assembly of PLGA Patchy Particles and Their Potential Applications in Biomedical Imagingelation for enhanced cell seeding and proliferation in regenerative medicine applications
    Langmuir, 2016, 32 (31), pp 7929–7942; Published 10 jun 2016
  5. N. Kamal, G. Fredman, J.J.R. Fojas, M. Subramanian, W. II Choi, K. Zepeda, C. Vilos, M. Yu, S. Gadde, J. Wu, J. Milton, R. Carvalho Leitao, L.R. Fernandes, M. Hasan, H. Gao, V. Nguyen, J. Harris, I. Tabas,O.C. Farokhzad
    Targeted Interleukin-10 Nanotherapeutics Developed with a Microfluidic Chip Enhance Resolution of Inflammation in Advanced Atherosclerosis
    ACS Nano, 2016, 10 (5), pp 5280–5292; Published May 2016

2015
  1. B. Yameen, C .Vilos, W.I. Choi, A. Whyte, J. Huang, L. Pollit, O.C. Farokhzad
    Drug Delivery Nanocarriers from Fully Degradable PEGConjugated Polyester with Reduction-Responsive Backbone
    Chem. Eur. J. 2015, 21,11325 –11329; Published 3 Aug 2015
  2. M. Muñoz, C. Vilos, M. Cantín
    Prothrombin C20209T mutation in deep vein thrombosis: a case report
    Int J Clin Exp Med. 2015; 8(7): 11225–11229; Published 15 Jul 2015
  3. C. Vilos, L.A. Velasquez, P.I. Rodas, K. Zepeda, S-J. Bong, N. Herrera, M. Cantin, F. Simon, L. Constandil.
    Preclinical development and in vivo efficacy of ceftiofur-PLGA microparticles
    PLoS ONE 10(4): e0123335.; Published 27 April 2015
  4. P. Solar, G. González, C. Vilos, N. Herrera, N. Juica, M. Moreno, F. Simon, L. Velásquez.
    Multifunctional polymeric nanoparticles doubly loaded with SPION and ceftiofur retain their physical and biological properties
    Journal of Nanobiotechnology 2015 13:14; Published: 13 Feb 2015

2014
  1. C. Vilos
    Nanotechnology in Preclinical and Clinical Drug Development
    Int. J. Med. Surg. Sci., 1(1):73-93, 2014
  2. W. Choi, N. Kamaly, L. Riol-Blanco, I-H. Lee, J. Wu, A. Swami, C. Vilos, B. Yameen, M. Yu, J. Shi, I. Tabas, U. von Andrian, S. Jon, O.C. Farokhzad
    A Solvent-free Thermosponge Nanoparticle Platform for Efficient Delivery of Labile Proteins
    Nano Lett., 2014, 14 (11), pp 6449–6455; Published (Web) 21 Oct 2014
  3. B. Yameen, W.I. Choi, C. Vilos, A. Swami, J. Shi, O.C. Farokhzad
    Insight into nanoparticle cellular uptake and intracellular targeting
    Journal of Controlled Release 190, 485-499
  4. C. Vilos, L. Constandil, P. I. Rodas, M. Cantin, K. Zepeda, N. Herrera, L. A. Velasquez
    Evaluation of ceftiofur–PHBV microparticles in rats
    Journal: Drug Design, Development and Therapy 2014: 8, 651-666

2013
  1. C. Vilos, F.A. Morales, P.A. Solar, N.S. Herrera, F.D. Gonzalez-Nilo, D.A. Aguayo, H.L. Mendoza, J. Comer, M.L. Bravo, P.A. González. S. Kato, M.A. Cuello, C. Alonso, E.J. Bravo, E.L. Bustamante, G.I. Owen, L.A. Velásquez
    Paclitaxel-PHBV nanoparticles and their toxicity to endometrial and primary ovarian cancer cells
    Biomaterials 34 (16), 4098-4108
  2. C. Vilos, M. Gutiérrez, R. Escobar, F. Morales, J. Denardin, L. Velásquez and D. Altbir
    Superparamagnetic Poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) Nanoparticles For Biomedical Applications
    Electron. J. Biotechnol. vol.16 no.5; Published Sep 2013

2012
  1. P. Miranda, I. Suazo Galdames, D. Zavando, P. Arenas, L. Velásquez, C. Vilos, M. Cantín
    In vivo biocompatibility of the PLGA microparticles in parotid gland
    Rom J Morphol Embryol (in press)

2010
  1. M. Cantín, C. Vilos and G.I. Suazo
    Nanodentistry: the Future of Dentistry Based on Nanotechnology Systems
    Int. J. Odontostomat., 4(2) 127-132

2011
  1. L. Acuña, G.I. Suazo, D. Zavando, S. Elgueta, L. Velásquez, C. Vilos and M. Cantín
    Morphometric and histopathologic changes in skeletal muscle induced for injectable PLGA microparticles
    Int. J. Morphol., 29(2) 403-408
  2. A. Tapia, C. Vilos, J.C. Marín, H. Croxatto, L. Devoto
    Bioinformatic detection of E47, E2F1 and SREBP1 transcription factors as potential regulators of genes associated to acquisition of endometrial receptivity
    Reprod Biol Endocrinol 9, 14
  3. J. Shi, Z. Xiao, A.R. Votruba, C. Vilos, O.C Farokhzad
    Differentially charged hollow core/shell lipid-polymer-lipid hybrid nanoparticles for small interfering RNA delivery
    Angew Chem Int Ed Engl 50, 7027-31

2012
  1. C. Vilos and L. Velásquez
    Therapeutic strategies based on polymeric microparticles
    Journal of Biomedicine and Biotechnology Volume 2012 (2012), Article ID 672760, 9 pages; Accepted 13 March 2012
  2. C. Vilos, L. Constandil, N. Herrea, P. Solar, J. Escobar-Fica and L. Velásquez
    Ceftiofur-loaded PHBV microparticles: a potential formulation for a long acting antibiotic to treat animal infections
    Electronic Journal of Biotechnology, Vol 15, No 4 (2012); Published 15 Jul 2012

back

Associated Institutions: