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Associate researchers

Luis Constandil Córdova

Phone(s): Phone: (56-2) 718 1092 , (56-2) 6812108
Laboratorio de Neurobiología, Facultad de Química y Biologia, Universidad de Santiago de Chile.
Avda. Libertador Bernardo OHiggins 3363, Estación Central, Santiago, Chile.

Current Occupation

  • Associate Researcher.

Professional Degree

  • Licenciate in Biological Sieneces, Pontificia Universidad Católica de Chile.
  • Doctor in Biological Sciences, Pontificia Universidad Católica de Chile.

Research Areas

  • Neurobiology.
  • Pain.
  • Animal Behaviour.


  • DYCIT 02-0843CC “Role of cortical glial in the corticofuga modulation of trigeminal nociceptive inputs: Potential target for new therapies for craniofacial pain ” 2008-2010. Principal Researcher.
  • DYCIT 020343CC. “Involvement of cortical circuits in orofacial pain modulation: Anatomic-functional studies in a model of nociception in the rat trigeminal” 2003-2004. Principal Researcher.
  • DYCIT 020343HK. “Role of spinal glia in the chronic pain pathogenesis: Neurophysiological study in an experimental monoarthritis model”. 2001-2003. Co-principal Reasercher.
  • FONDECYT 1090476. “A putative role for BDNF in generating a transcription-dependent feed-forward loop in the spinal dorsal horn, and its involvement in the persistence of neuropathic pain” 2009-2011. Co-principal Reasercher.
  • FONDECYT 1070115. “Role of spinal glia in the chronic pain pathogenesis: study neurophysiologic in an experimental monoarthritis model with human projection. 2007-2009. Co-principal Reasercher.
  • FONDECYT 1050099. “Role of cortico-trigeminal circuits and mediators in the etiopatiogénia of migraine: an experimental study with human projections”. 2005-2007. Principal Researcher.
  • FONDECYT 1000025. ” Somatostatinérgica innervation of the brainstem and their role in the modulation of respiratory pattern generator. Study in newborn mice”. 2000-2002. Co-principal Reasercher.
  • FONDECYT 2950084. “Characterization of the suprachiasmatic nucleus as circadian oscillator in the fetal lamb”. 1995-1996. Principal Researcher.
  • ECOS-CONICYT C08 S03 “Studies of the neurobiological mechanisms involved in the origin of headaches”. 2009-2011. Principal Researcher.
  • ECOS-CONICYT C04 S01 “Mechanisms of cortical plasticity involved in the pathophysiology of orofacial pain”. 2005-2007. Principal Researcher.
  • ECOS-CONICYT C00S02. ” Potentiation of antinociceptive effect of an antidepressant for an antagonist of 5-HT1A receptors: a study of the action mechanism”. 2001-2003. Co-principal Reasercher.


  1. S. Lux, N. Lobos, C. Lespay-Rebolledo, E. Salas-Huenuleo, M.J. Kogan, C. Flores, M. Pinto, A. Hernandez, T. Pelissier, L. Constandil
    The antinociceptive effect of resveratrol in bone cancer pain is inhibited by the Silent Information Regulator 1 inhibitor selisistat
    Journal of Pharmacy and Pharmacology, 71 (2019), pp. 816–825

  1. V. Cazanga, A. Hernandez, B. Morales, T. Pelissier, L. Constandil
    Antinociception Induced by Copper Salt Revisited: Interaction with Ketamine in Formalin-Induced Intraplantar and Orofacial Pain in Mice
    Journal of Oral & Facial Pain and Headache 32 (2018) 247–257
  2. C. Carvallo, D. Contreras, G. Ugarte, R. Delgado, F. Pancetti, C. Rozas, R. Piña, L. Constandil, M.L. Zeise, B. Morales
    Single and Repeated Administration of Methylphenidate Modulates Synaptic Plasticity in Opposite Directions via Insertion of AMPA Receptors in Rat Hippocampal Neurons
    Frontiers in Pharmacology 9 (2018) 1485 - 1502
  3. J. Retamal, A. Reyes, P. Ramirez, D. Bravo, A. Hernandez, T. Pelissier, L. Villanueva, L. Constandil
    Burst-Like Subcutaneous Electrical Stimulation Induces BDNF-Mediated, Cyclotraxin B-Sensitive Central Sensitization in Rat Spinal Cord
    Front. Pharmacol. 9:1143

  1. J.L. Marcos, D. Galleguillos, T. Pelissier, A. Hernández, L. Velásquez, L. Villanueva, L. Constandil
    Role of the spinal TrkB-NMDA receptor link in the BDNF-induced long-lasting mechanical hyperalgesia in the rat: A behavioural study
    Eur. J. Pain. 21 (2017) 1688-1696

  1. D. Bravo, C.J. Maturana, T. Pelissier, A. Hernández, L. Constandil
    Interactions of pannexin 1 with NMDA and P2X7 receptors in centralnervous system pathologies: Possible role on chronic pain
    Pharmacological Research 101 (2015) 86–93; Published Nov 2015

  1. C. Vilos, L. Constandil, P. I. Rodas, M. Cantin, K. Zepeda, N. Herrera, L. A. Velasquez
    Evaluation of ceftiofur–PHBV microparticles in rats
    Journal: Drug Design, Development and Therapy 2014: 8, 651-666

  1. F. Morales, L. Constandil, T. Pelissier, A. Hernández, C. Laurido
    Antinociceptive interaction of (+/-)-CPP and propentofylline in monoarthritic rats
    Arthritis Res Ther. 14(4):R196
  2. L. Constandil, M. Goich, A. Hernández, L. Bourgeais, M. Cazorla, M. Hamon, L. Villanueva, T. Pelissier
    Cyclotraxin-B, a new TrkB antagonist, and glial blockade by propentofylline, equally prevent and reverse cold allodynia induced by BDNF or partial infraorbital nerve constriction in mice.
    J Pain. 13(6):579-89
  3. C. Laurido, A. Hernández, T. Pelissier, L. Constandil
    Antinociceptive effect of rat D-serine racemase inhibitors, L-serine-O-sulfate, and L-erythro-3-hydroxyaspartate in an arthritic pain model.
    Scientific World Journal 2012, 279147

  1. L. Constandil, R. Aguilera, M. Goich, A, Hernández, P. Alvarez, C. Infante, T. Pelissier
    Involvement of spinal cord BDNF in the generation and maintenance of chronic neuropathic pain in rats.
    Brain Res Bull. 86(5-6):454-459

  1. R. Noseda, L. Constandil, L. Bourgeais, M. Chalus, L. Villanueva
    Changes of meningeal excitability mediated by corticotrigeminal networks: a link for the endogenous modulation of migraine pain
    The Journal of Neuroscience, 27 October 2010, 30(43): 14420-14429; Published 27 Oct 2010
  2. H. Burgos, A. Castillo, O. Flores, G. Puentes, C. Morgan, A. Gatica, C. Cofré, A. Hernández, C. Laurido, L. Constandil
    Effect of modafinil on learning performance and neocortical long-term potentiation in rats
    Brain Res Bull 83(5), 238-244

  1. P. Alvarez, A. Brun, A. Labertrandie, J. Lopez, A. Correa, L. Constandil, A. Hernández, and T. Pelissier
    Antihyperalgesic effects of clomipramine and tramadol in a model of posttraumatic trigeminal neuropathic pain in mice
    J Orofac Pain. 25(4):354-263

  1. C. Vilos, L. Constandil, N. Herrea, P. Solar, J. Escobar-Fica and L. Velásquez
    Ceftiofur-loaded PHBV microparticles: a potential formulation for a long acting antibiotic to treat animal infections
    Electronic Journal of Biotechnology, Vol 15, No 4 (2012); Published 15 Jul 2012


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